Author

Saori Haigo

Published on SDB CoRe: Mar 4 2013

Morphogenesis: Cell Movements; Cell Shape Changes; Cell/Tissue Polarity
The Germline: Oogenesis
Organism: Drosophila
Stage of Development: Oogenesis

Object Description

This image shows four Drosophila egg chambers developing within an ovariole.  They are (from smallest to largest) at stage 4, 6, 7, and 9.  During egg development the egg chamber or follicle goes from a sphere shape (stage 4) to an ellipsoid shape (stages 6-9).  This shape change is achieved when the follicle rotates around its elongating axis during the early phase of follicle elongation (stages 6 and 7).  By stage 9 of development the follicle no longer rotates.  (See ‘Rotating Drosophila Egg Chambers’ movie for demonstration).  The transgenic flies in this image express indy-GFP (white rainbow), a cell membrane marker of the outer follicle cells, and Histone 2B-mRFP (red), a marker of cell nuclei.

This image was the 2011 Developmental Biology Student Cover Competition winner (Vol. 356, Issue 1).

References

Haigo, S.L., Bilder, D. Global tissue revolutions in a morphogenetic movement controlling elongation. Science, 2011, 331:1071-1074.

Bilder, D., Haigo, S.L. Expanding the morphogenetic repertoire: perspectives from the Drosophila egg. Dev Cell, 2012, 22:12-23.

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